SCORTEN and impaired renal function related to mortality of toxic epidermal necrolysis syndrome patients in the Asian population. (27th March 2012)

• Record Type: Journal Article
• Authors: Hu, C.‐H.; Chang, N.‐J.; Liu, E.K.‐W.; Chuang, S.‐S.; Chung, W.‐H.; Yang, J.‐Y.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 27:Number 5(2013:May)
• Page Start: 628
• Page End: 633
• Publication Date: 2012-03-27
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/j.1468-3083.2012.04502.x
• Languages: English
• ISSNs: 0926-9959

Abstract

Abstract: Background Toxic epidermal necrolysis syndrome (TEN) is a rare, life‐threatening, drug‐related skin reaction with a high mortality rate. To date, only a few studies with insufficient sample sizes have been conducted to analyse SCORTEN in Asian populations with TEN. Objective To analyse SCORTEN and other related factors that affect TEN patients in Taiwan. Methods A retrospective review of medical records of 101 patients with TEN from 1992 to 2009. Results There were 62 cases of adverse reactions to a single medication and 39 cases of idiopathic reaction, from multiple medications, or infectious pathogens, of 101 TEN patients. Of the seven individual SCORTEN parameters, only associate malignancy, detached or compromised body surface area >10%, serum urea and bicarbonate were statistically significant in the multivariate analysis. Factors such as 1.5 times baseline serum creatinine levels, urine output of less than 0.5 mL/kg for 6 h and acute renal failure were connected with subsequent mortality. Conclusion The SCORTEN score is effective in predicting the outcome in Taiwanese TEN patients. A number of factors are predictors of mortality. In our study, we determine renal insufficiency and failure to be a marker for predicting a poor outcome.