Reaction of arylboronic acids with 5-aryl-3-substituted-2-thioxoimidazolin-4-ones. Issue 49 (7th December 2016)

• Record Type: Journal Article
• Authors: Dlin, Egor A.; Averochkin, Gleb M.; Finko, Alexander V.; Vorobyeva, Nataliya S.; Beloglazkina, Elena K.; Zyk, Nikolay V.; Ivanenkov, Yan A.; Skvortsov, Dmitry A.; Koteliansky, Victor E.; Majouga, Alexander G.
• Is Part Of: Tetrahedron letters. Volume 57:Issue 49(2016)
• Page Start: 5501
• Page End: 5504
• Publication Date: 2016-12-07
• Subjects: Copper-catalyzed -- Thio-amides -- C-S coupling -- Arylboronic acids -- Biological activity; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.10.102
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Efficient route to novel S -aryl-3-substituted-2-thioxoimidazolin-4-ones via a copper catalyzed coupling reaction. Mild conditions with good to excellent yields in short reaction times. Potential applications in synthetic and medicinal chemistry as a novel class of p53/MDM2 inhibitors. Abstract: A convenient and efficient catalytic procedure for the selective S -arylation of 2-thioxoimidazolidin-4-ones to give novel S -aryl substituted 2-thiohydantoins under mild reaction conditions using arylboronic acids is described. The anticancer activity of the compounds were evaluated in vitro .