A marginal structural model for recurrent events in the presence of time‐dependent confounding: non‐specific effects of vaccines on child hospitalisations. (31st August 2016)

• Record Type: Journal Article
• Authors: Jensen, Aksel K. G.; Ravn, Henrik; Sørup, Signe; Andersen, Per
• Is Part Of: Statistics in medicine. Volume 35:Number 27(2016)
• Page Start: 5051
• Page End: 5069
• Publication Date: 2016-08-31
• Subjects: marginal structural model -- recurrent events -- continuously updated weights -- non‐specific effects of vaccination -- multi‐state model; Medical statistics -- Periodicals; Statistique médicale -- Périodiques; Statistiques médicales -- Périodiques; 610.727
• DOI: 10.1002/sim.7060
• Languages: English
• ISSNs: 0277-6715

Abstract

Abstract : Using a Danish register‐based study on childhood vaccination and hospitalisation as motivation, a marginal structural model for recurrent events is studied. The model addresses a number of challenges which may be seen more generally in large register‐based cohort studies. One is to adjust for a time‐dependent confounder when studying the effect of a time‐varying exposure on a recurrent event based on an analysis in continuous time. Another is to report results via a measure which is easy to interpret and communicate even though quite elaborate treatment regimes are considered. Lastly, the implementation of continuously updated weights implies a substantial computationally demanding workload. Copyright © 2016 John Wiley & Sons, Ltd.