The function of the DegP (HtrA) protein: Protease versus chaperone. Issue 11 (26th September 2016)

• Record Type: Journal Article
• Authors: Chang, Zengyi
• Other Names: Chang Zengyi guestEditor.
• Is Part Of: IUBMB life. Volume 68:Issue 11(2016)
• Page Start: 904
• Page End: 907
• Publication Date: 2016-09-26
• Subjects: periplasmic space -- protein quality control -- outer membrane protein biogenesis; Biochemistry -- Periodicals; Molecular biology -- Periodicals; 572.8
• DOI: 10.1002/iub.1561
• Languages: English
• ISSNs: 1521-6543

Abstract

Abstract: The DegP (or HtrA) is a highly conserved family of proteins functioning in all living organisms. It was initially identified as a protease functioning in the periplasmic space of the Gram‐negative bacterial cells. It was later reported to also exhibit chaperone activity and thus has been designated as a bifunctional protein. However, recent studies demonstrated that in living cells it more likely functions only as a protease with hardly detectable chaperone activities. In this review, I will summarize the evidences clarifying that DegP more likely only functions as a protease rather than as a chaperone in cells. © 2016 IUBMB Life, 68(11):904–907, 2016