Changes of the directional brain networks related with brain plasticity in patients with long-term unilateral sensorineural hearing loss. (28th January 2016)

• Record Type: Journal Article
• Authors: Zhang, G.-Y.; Yang, M.; Liu, B.; Huang, Z.-C.; Li, J.; Chen, J.-Y.; Chen, H.; Zhang, P.-P.; Liu, L.-J.; Wang, J.; Teng, G.-J.
• Is Part Of: Neuroscience. Volume 313(2016)
• Page Start: 149
• Page End: 161
• Publication Date: 2016-01-28
• Subjects: BAs Brodmann areas -- BOLD blood oxygen level dependent -- DCM dynamic causal modeling -- FDR false discovery rate -- fMRI functional MRI -- GC granger causality -- HL hearing level -- LUSNHL left long-term USNHL -- MNI Montreal Neurological Institute -- MRI MR imaging -- RUSNHL right long-term USNHL -- USNHL unilateral sensorineural hearing loss; unilateral sensorineural hearing loss -- entropy connectivity -- directional brain functional network -- cognitive function -- reorganization; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2015.11.042
• Languages: English
• ISSNs: 0306-4522

Abstract

Graphical abstract: Highlights: Left deafness leads to cross-modal plasticity in the non-auditory-deprived cortex. Right deafness fails to display plastic changes in the auditory cortex. There exists a different cross-modal plasticity in the congenital and acquired deafness. Cross-modal reorganization leads to changes of the directional brain networks. Abstract: Previous studies often report that early auditory deprivation or congenital deafness contributes to cross-modal reorganization in the auditory-deprived cortex, and this cross-modal reorganization limits clinical benefit from cochlear prosthetics. However, there are inconsistencies among study results on cortical reorganization in those subjects with long-term unilateral sensorineural hearing loss (USNHL). It is also unclear whether there exists a similar cross-modal plasticity of the auditory cortex for acquired monaural deafness and early or congenital deafness. To address this issue, we constructed the directional brain functional networks based on entropy connectivity of resting-state functional MRI and researched changes of the networks. Thirty-four long-term USNHL individuals and seventeen normally hearing individuals participated in the test, and all USNHL patients had acquired deafness. We found that certain brain regions of the sensorimotor and visual networks presented enhanced synchronous output entropy connectivity with the left primary auditory cortex in the left long-term USNHL individuals as compared with normally hearing individuals. Especially, the left USNHL showed more significant changes of entropy connectivity than the right USNHL. No significant plastic changes were observed in the right USNHL. Our results indicate that the left primary auditory cortex (non-auditory-deprived cortex) in patients with left USNHL has been reorganized by visual and sensorimotor modalities through cross-modal plasticity. Furthermore, the cross-modal reorganization also alters the directional brain functional networks. The auditory deprivation from the left or right side generates different influences on the human brain.