Studies on batch formulation of a kit for the preparation of the 99mTc-Ubiquicidin (29-41): An infection imaging agent. (January 2016)

• Record Type: Journal Article
• Authors: Arjun, Chanda; Mukherjee, Archana; Bhatt, Jyotsna; Chaudhari, Pradip; Repaka, Krishna Mohan; Venkatesh, Meera; Samuel, Grace
• Is Part Of: Applied radiation and isotopes. Volume 107(2016:Jan.)
• Page Start: 8
• Page End: 12
• Publication Date: 2016-01
• Subjects: Kit formulation -- Ubiquicidin (29–41) -- Infection imaging -- 99mTc-UBI (29-41); Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2015.09.009
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: The aim of this study was to formulate an indigenous cold kit of Ubiquicidin, UBI (29-41), for easy preparation of 99m Tc-UBI (29-41) to be used as an infection imaging agent. A two component kit with the peptide and SnCl2 as vial 1 and optimum amount of NaOH as vial 2 was successfully formulated as seen from the consistent radiochemical and pharmaceutical purity of the product over six consecutive batches of kits. The utility of the kit could be demonstrated through in-vitro and in vivo specificity of 99m Tc-UBI (29-41). Highlights: An indigenous cold kit of Ubiquicidin, UBI (29–41), for preparation of 99m Tc-UBI (29-41) for infection imaging was formulated. Simple ITLC method to calculate yield of 99m Tc-UBI (29-41) complex was established. Consistent batch production of UBI kit with acceptable criteria was demonstrated.