The evaluation of possible role of endocrine disruptors in central and peripheral precocious puberty. (1st September 2016)

• Record Type: Journal Article
• Authors: Buluş, Ayşe Derya; Aşci, Ali; Erkekoglu, Pinar; Balci, Aylin; Andiran, Nesibe; Koçer-Gümüşel, Belma
• Is Part Of: Toxicology mechanisms and methods. Volume 26:Number 7(2016)
• Page Start: 493
• Page End: 500
• Publication Date: 2016-09-01
• Subjects: Bisphenol A -- central precocios puberty -- endocrine disrupting chemical -- peripheral precocious puberty -- phthalate; Analytical toxicology -- Periodicals; Toxicology -- Periodicals; Toxicology -- Methodology -- Periodicals; 615.907
• DOI: 10.3109/15376516.2016.1158894
• Languages: English
• ISSNs: 1537-6516

Abstract

Abstract: Exposure to environmental chemicals can affect genetic and epigenetic molecular pathways and may cause altered growth and development. Among those exposures, endocrine-disrupting chemicals (EDCs) are of particular concern as humans are abundantly exposed to these chemicals by various means in every period of life. Several well-known environmental chemicals, including phthalates and bisphenol A (BPA), are classified as EDCs. These EDCs are suggested to play roles in early onset of puberty in girls. The aim of this study is to determine plasma phthalate (di(2-ethylhexyl)phthalate [DEHP] and its main metabolite mono(2-ethylhexyl)phthalate [MEHP]) and urinary BPA levels in girls with idiopathic central precocious puberty (CPP) and peripheral precocious puberty (PPP). This study was performed on newly diagnosed idiopathic central precocious puberty (CPP) patients ( n = 42) and peripheral precocious puberty (PPP) ( n = 42) patients, who were admitted to Keçiören Training and Research Hospital, Clinic of Pediatric Endocrinology between August 2012 and –July 2013. Nonobese healthy girls ( n = 50) were used as the control group. Urinary BPA levels were not statistically different in control, PPP and CPP groups (medians 10.91, 10.63 and 10.15 μg/g creatinine, respectively; p > 0.05). Plasma DEHP levels were significantly higher in PPP group when compared to control. Plasma MEHP levels were not significantly different in control and PPP groups ( p > 0.05). However, in CPP group, both plasma DEHP and MEHP levels were significantly higher than control and PPP groups. This study showed that phthalates might play a role in the occurence of CPP in girls.