When MFN2 (mitofusin 2) met autophagy: A new age for old muscles. Issue 11 (1st November 2016)

• Record Type: Journal Article
• Authors: Sebastián, David; Zorzano, Antonio
• Is Part Of: Autophagy. Volume 12:Issue 11(2016)
• Page Start: 2250
• Page End: 2251
• Publication Date: 2016-11-01
• Subjects: aging -- mitochondria -- mitophagy -- muscle -- sarcopenia; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2016.1215383
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: A long-standing quest is to define the mechanisms responsible for the mitochondrial dysfunction and accumulation of damaged mitochondria that occur during aging. Indeed, those defects are considered major contributors to the aging process. We have analyzed the effect of aging on the muscle expression of Mfn2 and the impact of Mfn2 ablation on muscle function. Our findings reveal that Mfn2 is repressed in muscle during aging, and that is a determinant for the inhibition of autophagy, and mitochondrial quality control, which lead to the accumulation of damaged mitochondria.