PH-dependent cytotoxic effects of extracts of the marine sponge Polymastia janeirensis on cancer cell lines. Issue 23 (1st December 2016)

• Record Type: Journal Article
• Authors: Biegelmeyer, Renata; Schröder, Rafael; Rambo, Douglas F.; Dresch, Roger R.; Carraro, João L. F.; Mothes B, Beatriz; Moreira, José Cláudio F.; da Frota Junior, Mario L. C.; Henriques, Amélia T.
• Is Part Of: Natural product research. Volume 30:Issue 23(2016)
• Page Start: 2734
• Page End: 2737
• Publication Date: 2016-12-01
• Subjects: Polymastia janeirensis -- chemical defence -- cytotoxic -- pH-dependent activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1143824
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The purpose of this work was to study the cytotoxic effects of marine sponge Polymastia janeirensis, which has been observed in the field to release an orange substance that is toxic to fish. The result showed that aqueous extract (pH 7.0) was highly cytotoxic to glioma (U87) and neuroblastoma (SHSY5Y) cancer cell lines (IC50 < 1.0 μg/mL). In addition, this extract showed potent antioxidant and procoagulant (decreased the clotting time by 1.7-fold) activities. Interestingly, the cytotoxic effects were pH-dependent since the viability of the cancer cells was not affected with the extract (pH 5.5). The close similarity between the aqueous extract (pH 7.0) and the orange liquid that is released by the sponge indicates that this potential chemical defence of P. janeirensis deserves further investigation. Abstract :