Angucycline antibiotics and its derivatives from marine-derived actinomycete Streptomyces sp. A6H. Issue 22 (16th November 2016)

• Record Type: Journal Article
• Authors: Hu, Zhijuan; Qin, Lele; Wang, Qianqian; Ding, Wanjing; Chen, Zhen; Ma, Zhongjun
• Is Part Of: Natural product research. Volume 30:Issue 22(2016)
• Page Start: 2551
• Page End: 2558
• Publication Date: 2016-11-16
• Subjects: Streptomyces sp. A6H -- angucycline -- hydrolysis -- semisynthesis; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1120730
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Vineomycin A1 (1 ) and B2 (2 ) were isolated from the culture broth of marine actinomycete Streptomyces sp. A6H. Five hydrolysis products were obtained by rational hydrolysis and methanolysis of the fermentation extract. Their structures were characterised as aquayamycin (3 ), vineomycinone B2 (4 ), 9-C-D -olivosyltetrangulol (5 ), 7-O-methylgaltamycinone (6 ) and vineomycinone B2 methyl ester (7 ). In addition to these compounds, two ester derivatives, vineolactone A (8) and vineomycinone B2 benzyl ester (9 ) of compound4 were generated semisynthetically. Compound6 is a new analogue of galtamycinone, while compounds8 and9 are new members of vineomycins. Cytotoxic activities and antimicrobial activities were determined for all compounds. The results indicate that only compound1 showed significant activities with IC50 value of 0.34 μM against H1975 and MIC value of 4 μg/mL against Staphylococcus aureus. Abstract :