Insulin sensitivity, body composition and adipose depots following 12 w combined endurance and strength training in dysglycemic and normoglycemic sedentary men. (7th August 2016)

• Record Type: Journal Article
• Authors: Langleite, Torgrim Mikal; Jensen, Jørgen; Norheim, Frode; Gulseth, Hanne Løvdal; Tangen, Daniel Steensen; Kolnes, Kristoffer Jensen; Heck, Ansgar; Storås, Tryggve; Grøthe, Guro; Dahl, Marius Adler; Kielland, Anders; Holen, Torgeir; Noreng, Hans Jørgen; Stadheim, Hans Kristian; Bjørnerud, Atle; Johansen, Egil Ivar; Nellemann, Birgitte; Birkeland, Kåre Inge; Drevon, Christian A.
• Is Part Of: Archives of physiology and biochemistry. Volume 122:Number 4(2016)
• Page Start: 167
• Page End: 179
• Publication Date: 2016-08-07
• Subjects: Adipokines -- muscle fat -- myokines -- prediabetes -- visceral fat; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2016.1202985
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Context : Insulin resistance and dysglycemia are associated with physical inactivity and adiposity, and may be improved by exercise. Objective : Investigate the effect of exercise on insulin sensitivity, body composition and adipose depots in sedentary men with ( n = 11) or without ( n = 11) overweight and dysglycemia. Material and methods : Euglycemic-hyperinsulinemic clamp, ankle-to-neck MRI, MRS, muscle and adipose tissue biopsies before and after 12 weeks combined strength and endurance exercise. Results : Insulin sensitivity, VO2 max, strength, whole-body and muscle fat content, and abdominal adipose depots were improved without obvious differences between normo- and dysglycemic men. Hepatic fat, waist circumference and subcutaneous adipose tissue were reduced in the dysglycemic group. For both groups plasma adiponectin was reduced, whereas IL-6 was unchanged. Visceral fat was preferentially lost compared with other adipose depots. Discussion and conclusion : Body composition, fat distribution and insulin sensitivity improved following training in sedentary middle-aged men with and without dysglycemia.