A review of advances in two-dimensional thin-layer chromatography. Issue 14 (26th August 2016)

• Record Type: Journal Article
• Authors: Rabel, Fred; Sherma, Joseph
• Is Part Of: Journal of liquid chromatography & related technologies. Volume 39:Issue 14(2016)
• Page Start: 627
• Page End: 639
• Publication Date: 2016-08-26
• Subjects: Graft thin-layer chromatography -- high-performance thin-layer chromatography -- multidimensional thin-layer chromatography -- review -- thin-layer chromatography -- two-dimensional thin-layer chromatography; Liquid chromatography -- Periodicals; Chromatographic analysis -- Periodicals; Separation (Technology) -- Periodicals; Biotechnology -- Periodicals; Chromatography, Liquid -- Periodicals; 543.8405
• DOI: 10.1080/10826076.2016.1214844
• Languages: English
• ISSNs: 1082-6076

Abstract

ABSTRACT: Although there are many simple thin-layer chromatography (TLC) separations, many more are complex and involve more than a few components, that means having to use special high-performance TLC (HPTLC) plates or microspotting or banding devices to increase its resolving power if developing in only one direction. However, adding a second development to perform two-dimensional TLC (2D TLC) allows even better resolution of complex samples. This is because different modes of chromatography are being invoked by the use of one stationary phase with two mobile phases, bilayer plates, graft TLC, or multidimensional TLC. This paper is a review of recent applications that have benefitted from using 2D TLC in its various forms. They were chosen for their variety of sample types as well as the unique choices of plates and/or mobile phases made by the researchers to yield improved separations. GRAPHICAL ABSTRACT: