SNAP-25 gene variations and attention-deficit hyperactivity disorder in Iranian population. (1st November 2016)

• Record Type: Journal Article
• Authors: Zarrabi Alhosseini, Mahjoubeh; Jamshidi, Javad; Zare Bidoki, Alireza; Ganji, Saeid; Eslami Amirabadi, Mohammad Reza; Emamalizadeh, Babak; Taghavi, Shaghayegh; Shokraeian, Parasto; Mohajerani, Fatemeh; Darvish, Hossein
• Is Part Of: Neurological research. Volume 38:Number 11(2016)
• Page Start: 959
• Page End: 964
• Publication Date: 2016-11-01
• Subjects: ADHD -- SNAP-25 -- Variation -- Polymorphism -- Iranian; Neurology -- Periodicals; Neurosciences -- Periodicals; 616.8005
• DOI: 10.1080/01616412.2016.1232548
• Languages: English
• ISSNs: 0161-6412

Abstract

Abstract : Objectives: Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition of childhood characterized by persistent symptoms of hyperactivity, inattention, and impulsivity. The objective of this study was to investigate the association of synaptosomal-associated protein of 25 kDa ( SNAP - 25 ) gene variants with ADHD. Methods: A case-control study with a total of 150 children with ADHD (mean age 9.61; range 6–16; gender ratio 105m/45f) and 150 normal children (mean age 10.02; range 6–16; gender ratio 98m/52f) was conducted. Genomic DNA was extracted from peripheral blood of all samples and SNPs rs78428954 and rs3746544 located in SNAP - 25 gene were genotyped. Results: Our analysis indicated that there is no significant association between none of studied variants in SNAP - 25 and ADHD. Discussion: To our knowledge, it is the first report of SNAP - 25 genotyping in Iranian patients with ADHD. Further investigations with larger populations are needed in order to clarify the exact role of SNAP - 25 variations in susceptibility to ADHD.