Efficient and green microwave-assisted one-pot synthesis of azaindolizines in PEG-400 and water. Issue 21 (1st November 2016)

• Record Type: Journal Article
• Authors: Wagare, Devendra S.; Farooqui, Mazhar; Keche, Tushar D.; Durrani, Ayesha
• Is Part Of: Synthetic communications. Volume 46:Issue 21(2016)
• Page Start: 1741
• Page End: 1746
• Publication Date: 2016-11-01
• Subjects: 2-Aminopyridines -- imidazo[1, 2-a]pyridines -- microwave irradiation -- NBS -- PEG-400–water; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2016.1223314
• Languages: English
• ISSNs: 0039-7911

Abstract

ABSTRACT: A facile, convenient, environmentally benign, and one-pot synthesis of imidazo[1, 2-a]pyridines from 2-aminopyridines and in-situ generated phenacyl bromides under microwave irradiation in polyethylene glycol (PEG-400) and water (1:2) has been developed. The protocol provides a better alternative to the existing method as it involves utilization of in-situ-generatedα -bromoacetophenones, avoids the use of lachrymatricα -haloketones as well as volatile toxic organic solvents, and reduces the reaction time to obtain excellent yield. GRAPHICAL ABSTRACT: