A new dual-channel ratiometric fluorescent chemodosimeter for Cu2+ and its imaging in living cells. Issue 47 (23rd November 2016)

• Record Type: Journal Article
• Authors: Fan, Zheng; Ye, Jia-Hai; Bai, Yang; Bian, Song; Wang, Xiaolong; Zhang, Wenchao; He, Weijiang
• Is Part Of: Tetrahedron letters. Volume 57:Issue 47(2016)
• Page Start: 5281
• Page End: 5285
• Publication Date: 2016-11-23
• Subjects: Ratiometric -- BODIPY -- Chemodosimeter -- Cu2+ -- Fluorescence -- Living cell imaging; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.10.050
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A new ratiometric chemodosimeter 1 was developed for recognizing Cu 2+ efficiently. Chemodosimeter 1 works well within a wide range pH and physiological conditions. 1 shows high selectivity and low detection limitation (0.2 μM) in aqueous medium. 1 can be successfully utilized in fluorescent imaging in living cells for Cu 2+ detection. Abstract: A new BODIPY derivative bearing hydrazone and hydrazide moieties was developed as an efficient dual-channel ratiometric fluorescence chemodosimeter1 for Cu 2+ in neutral aqueous medium via Cu 2+ -mediated hydrolysis of CN bond in hydrazone unit. Confocal microscopy experiments have demonstrated that chemodosimeter1 could also be used in live cells for the fast detection of Cu 2+ .