Metal–Catalyst-Free Green and efficient synthesis of five and six membered fused N-heterocyclic quinazoline derivatives. Issue 46 (16th November 2016)

• Record Type: Journal Article
• Authors: Madhubabu, M.V.; Shankar, R.; Reddy, G. Rajeshwar; Rao, T. Srinivasa; Basaveswara Rao, Mandava V.; Akula, Raghunadh
• Is Part Of: Tetrahedron letters. Volume 57:Issue 46(2016)
• Page Start: 5033
• Page End: 5037
• Publication Date: 2016-11-16
• Subjects: PEG -- MCR -- Water -- Dihydroisoindolo[2, 1-a]quinazoline-5, 11-dione; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.09.094
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: An efficient and green approach for the synthesis of Tetracyclic nitrogen-bridgehead compounds. Synthetic approach involves construction of two new rings via sequential CN bond formation. Recover and recyclability of solvent was established. Abstract: An efficient and green approach has been developed for the construction of Tetracyclic nitrogen-bridgehead compounds were designed and synthesized in good yields. The reaction of easily prepared 3-bromoisobenzofuran-1(3 H )-one with isatoic anhydride and amines gave the desired isoindoloquinazolinone derivatives in moderate to good yields. It is also amenable for scale-up.