Structure–activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors. Issue 21 (1st November 2016) - Tong, Ling
Graphical abstract: Abstract: We describe the impact of proline modifications, in our tetracyclic-indole based series of nonstructural protein 5A (NS5A) inhibitors, to their replicon profiles. This work identified NS5A inhibitors with an improved and flattened resistance profiles.