1, 10-Phenanthroline and its derivatives are novel hatching stimulants for soybean cyst nematodes. Issue 21 (1st November 2016)

• Record Type: Journal Article
• Authors: Nonaka, Shiori; Katsuyama, Tsutomu; Kondo, Tatsuhiko; Sasaki, Yasuyuki; Asami, Tadao; Yajima, Shunsuke; Ito, Shinsaku
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 21(2016)
• Page Start: 5240
• Page End: 5243
• Publication Date: 2016-11-01
• Subjects: Soybean cyst nematode -- Hatching stimulants -- Glycinoeclepin -- 1, 10-Phenanthroline -- 2, 2′-Bipyridine -- Chelating agents; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.09.052
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Soybean cyst nematode (SCN), Heterodera glycines Ichinohe, is a plant-parasitic nematode and one of the most serious soybean pests. Herein, we present the heterocyclic compound 1, 10-phenanthroline (Phen) and its derivatives as novel hatching stimulants for SCN. Phen treatment promoted hatching of second-stage juveniles of SCNs in a concentration-dependent manner. In addition, the hatching of SCNs following treatment with Phen occurred more rapidly than that following treatment with the known hatching stimulant, glycinoeclepin A (GEA). Furthermore, the co-application of Phen and GEA enhanced SCN hatching rate compared with that of Phen or GEA alone. A structure–activity relationship study for Phen derivatives suggested that 2, 2′-bipyridine is the essential structure of the SCN-hatching stimulants. These results suggest that Phen and its derivatives activate different hatching pathways of SCNs from GEA.