Cobalt(III)‐Catalyzed Intramolecular Cross‐Dehydrogenative C−H/X−H Coupling: Efficient Synthesis of Indoles and Benzofurans. Issue 45 (30th September 2016)

• Record Type: Journal Article
• Authors: Ghorai, Jayanta; Reddy, Angula Chandra Shekar; Anbarasan, Pazhamalai
• Is Part Of: Chemistry. Volume 22:Issue 45(2016)
• Page Start: 16042
• Page End: 16046
• Publication Date: 2016-09-30
• Subjects: benzofuran -- C−H activation -- cobalt -- cross-dehydrogenative coupling -- indole; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201604111
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: An efficient cobalt(III)‐catalyzed intramolecular cross‐dehydrogenative C−H/N−H coupling of ortho ‐alkenylanilines has been developed utilizing O2 as a terminal oxidant. The developed reaction tolerates various reactive functional groups and allows the synthesis of diverse indole derivatives in good to excellent yields. The method was successfully extended to the synthesis of benzofurans through the intramolecular cross‐dehydrogenative C−H/O−H coupling of ortho ‐alkenylphenols. Abstract : Cobalt coupling double‐crossed : Efficient and general cobalt(III)‐catalyzed intramolecular cross‐dehydrogenative C−H/N−H coupling of ortho ‐alkenylanilines have been developed utilizing molecular oxygen as terminal oxidant for the synthesis of diverse indole derivatives in good to excellent yields. Successful extension of the method was demonstrated through intramolecular cross‐dehydrogenative C−H/O−H coupling of ortho ‐alkenylphenols for the synthesis of benzofurans.