Bio‐ and chemical syntheses of mangiferin and congeners. (6th April 2016)

• Record Type: Journal Article
• Authors: Ehianeta, Teddy Stephen; Laval, Stéphane; Yu, Biao
• Other Names: Chi Yuling guestEditor.
• Is Part Of: BioFactors. Volume 42:Number 5(2016:Sep./Oct.)
• Page Start: 445
• Page End: 458
• Publication Date: 2016-04-06
• Subjects: mangiferin -- C‐glycoside -- xanthone -- biosynthesis -- chemical synthesis; Vitamins -- Physiological effect -- Periodicals; Trace elements -- Physiological effect -- Periodicals; Growth factors -- Physiological effect -- Periodicals; Plant growth promoting substances -- Physiological effect -- Periodicals; Biochemistry -- Periodicals; Nutritional Physiological Phenomena -- Periodicals; Trace Elements -- metabolism -- Periodicals; Vitamins -- metabolism -- Periodicals; Molecular Biology -- Periodicals; 612.399
• DOI: 10.1002/biof.1279
• Languages: English
• ISSNs: 0951-6433

Abstract

Abstract: Mangiferin (2 C ‐β‐d ‐glucopyranosyl‐1, 3, 6, 7‐tetrahydroxyxanthone) is a xanthone C ‐glycoside occurring in many plant species. Composed of a glucose unit C1→2 linked to a 1, 3, 6, 7‐tetrahydroxyxanthone aglycone, mangiferin exhibits a wide range of biological activities, which recently renewed its interest as a potential pharmacophore. Mangiferin is mainly isolated after extraction procedures from natural sources alongside with its isoforms isomangiferin, homomangiferin, and neomangiferin. However, enzymatic and chemical approaches have been developed to access these phytochemicals, which address the challenging construction of the C‐ glycosidic linkage. In addition, both approaches have been exploited to modify the aglycone and the sugar moiety in order to afford analogues with specific and improved pharmacological activities. Herein, we provide a comprehensive review on the biosynthesis and chemical synthesis of mangiferin and its congeners. © 2016 BioFactors, 42(5):445–458, 2016