Cryoprecipitate AHF vs. fibrinogen concentrates for fibrinogen replacement in acquired bleeding patients – an economic evaluation. Issue 3 (1st June 2016)

• Record Type: Journal Article
• Authors: Okerberg, C. K.; Williams, L. A.; Kilgore, M. L.; Kim, C. H.; Marques, M. B.; Schwartz, J.; Pham, H. P.
• Is Part Of: Vox sanguinis. Volume 111:Issue 3(2016)
• Page Start: 292
• Page End: 298
• Publication Date: 2016-06-01
• Subjects: blood product -- cost‐effectiveness -- cryoprecipitate -- fibrinogen concentrate -- haemorrhage -- plasma derivative -- RiaSTAP® -- transfusion; Blood -- Periodicals; Blood -- Transfusion -- Periodicals; Immunohematology -- Periodicals; Immunopathology -- Periodicals; 615.39
• DOI: 10.1111/vox.12417
• Languages: English
• ISSNs: 0042-9007

Abstract

Abstract : Background: Fibrinogen repletion in patients with acquired bleeding disorders can be accomplished by transfusing cryoprecipitate AHF (cryo) or fibrinogen concentrate (FC); thus, we undertook an economic evaluation from the transfusion service perspective regarding the use of cryo vs. FC in patients with acquired bleeding. Methods: We created a model comparing the cost of cryo vs. FC from the transfusion service perspective. A patient with acquired bleeding requiring fibrinogen replacement could receive either 15–20 cryo units or 3–4 g FC, consistent with the guidelines from the European Task Force for Advanced Bleeding Care in Trauma . All model parameters were estimated from institutional experiences and the medical literature. Additionally, a survey of US Transfusion Medicine fellowship directors was conducted. Results: After adjusting for 28% wastage and technologist salary, cryo cost is $414/5‐unit pool. Depending on the dose, FC is more expensive by $976‐$1303. To be competitive with cryo, FC cost must decrease by 44% or be shown to save 0·25–0·66 ICU days. Of the 30 survey replies, 96·7% of US centres do not use FC for acquired bleeding with the top three reasons being cost (30%), off‐label usage (27%) and insufficient evidence for usage (20%). Only 47% are willing to pay more for FC, with $437/g as the median amount. Conclusion: Fibrinogen concentrate is more expensive than cryo, even after adjusting for cryo wastage. To be economically competitive with cryo, FC must cost $414/g, or save on ICU length of stay, consistent with the survey's results.