Invited commentary: mapping the alteration in glutamate with GluCEST MRI in a mouse model of dopamine deficiency: An Editorial Highlight for 'Mapping the alterations in glutamate with GluCEST MRI in a mouse model of dopamine deficiency'. Issue 3 (16th October 2016)

• Record Type: Journal Article
• Authors: Cumming, Paul; Gallinat, Jürgen
• Is Part Of: Journal of neurochemistry. Volume 139:Issue 3(2016)
• Page Start: 346
• Page End: 348
• Publication Date: 2016-10-16
• Subjects: Neurochemistry -- Periodicals; 616.8042
• DOI: 10.1111/jnc.13759
• Languages: English
• ISSNs: 0022-3042

Abstract

Abstract : Read the highlighted article 'Mapping the alterations in glutamate with GluCEST MRI in a mouse model of dopamine deficiency' on page432 . Abstract : This Editorial highlights a study by Bagga and coworkers (2016) in the current issue of the Journal of Neurochemistry entitled "Mapping the alteration in brain glutamate with glutamate chemical exchange saturation transfer (GluCEST) magnetic resonance imaging in mice with MPTP‐induced parkinsonism, a model of dopamine deficiency." Using their spectroscopic procedure, Bagga et al . discern unexpected relative increases in the cortical glutamate content of parkinsonian mice. Their results suggest the occurrence of a simple relationship between striatal astrogliosis and tissue glutamate content, presumably in relation to enhanced glutamate/glutamine cycling. This raises the question of whether the reported 20% increase in the striatal glutamate content is an epiphenomenon of the neurotoxicity, or has particular relevance to dysfunction of the dopamine‐depleted striatum and its associated cerebral cortex. Read the highlighted article 'Mapping the alterations in glutamate with GluCEST MRI in a mouse model of dopamine deficiency' on page432 .