Primary Sjögren's syndrome is associated with significant cognitive dysfunction. (25th July 2016)

• Record Type: Journal Article
• Authors: Tezcan, Mehmet Engin; Kocer, Emine Belgin; Haznedaroglu, Seminur; Sonmez, Cemile; Mercan, Ridvan; Yucel, Aysegul Atak; Irkec, Ceyla; Bitik, Berivan; Goker, Berna
• Is Part Of: International journal of rheumatic diseases. Volume 19:Number 10(2016)
• Page Start: 981
• Page End: 988
• Publication Date: 2016-07-25
• Subjects: anti‐glutamate‐receptor antibody -- cognitive functions -- neurobehavioral manifestations -- Sjögren's syndrome; Rheumatology -- Periodicals; Rheumatology -- Asia -- Periodicals; Rheumatology -- Pacific Area -- Periodicals; Rheumatic Diseases -- Periodicals; Connective Tissue Diseases -- Periodicals; Immune System Diseases -- Periodicals; 616.723
• DOI: 10.1111/1756-185X.12912
• Languages: English
• ISSNs: 1756-1841

Abstract

Abstract: Aim: Cognitive dysfunction is a neurologic manifestation in primary Sjögren syndrome (PSS). On the other hand, several antibodies are related to cognitive dysfunction. The aim of this study is to assess the cognitive dysfunction of PSS patients via detailed neurologic tests. Moreover, its associations with antibodies were also evaluated. Method: Twenty‐eight female patients with PSS and 17 healthy controls comprised the study groups. Short‐term memory, long‐term memory, verbal learning, visual memory, visual spatial perception, attention, verbal frequency function, executive functions and information processing speed were evaluated with neurologic tests in both of the study groups. Furthermore, anti‐ N ‐methyl‐D‐aspartate (NMDA) type anti‐glutamate‐receptor antibody, anti‐ribosomal‐p and antiganglioside antibodies were assessed in the study groups. Results: The attention, data processing speed, verbal learning, short‐term verbal memory and visuo‐spatial perception performances were lower in the patients with PSS when compared to the healthy controls. The difference reached statistical significance in Paced Auditory Serial Addition Test ( P < 0.01), Serial Digit Learning Test ( P < 0.01), clock drawing ( P = 0.03), Auditory Verbal Learning Test immediate verbal memory ( P = 0.01) and Benton Judgement of Line Orientation Test ( P = 0.03). Even if antiganglioside antibodies were more likely to be present in the PSS group when compared to the healthy controls, no relationship was found between its positivity and cognitive dysfunction. Conclusion: Results of this study suggest that cognitive dysfunction is quite prevalent in PSS patients without being associated with studied antibodies.