A Pseudomonas aeruginosa‐secreted protease modulates host intrinsic immune responses, but how?. (16th September 2016)

• Record Type: Journal Article
• Authors: Cheng, Zhenyu
• Is Part Of: BioEssays. Volume 38:Number 11(2016:Nov.)
• Page Start: 1084
• Page End: 1092
• Publication Date: 2016-09-16
• Subjects: immunity -- pathogen -- protease -- signaling; Molecular biology -- Periodicals; Cytology -- Periodicals; Developmental biology -- Periodicals; 572.8
• DOI: 10.1002/bies.201600101
• Languages: English
• ISSNs: 0265-9247

Abstract

Abstract : Recently, we found that the Pseudomonas aeruginosa type II secreted protease IV functions as a unique Arabidopsis innate immunity elicitor. The protease IV‐activated pathway involves G protein signaling and raises the question of how protease elicitation leads to the activation of G protein‐mediated signaling, because plants do not appear to have metazoan‐like G protein‐coupled receptors. Importantly, our data suggest that Arabidopsis has evolved a mechanism to detect the proteolytic activity of a pathogen‐encoded protease, supporting the host‐pathogen arms race model. In the case of opportunistic multi‐host pathogens like P. aeruginosa, however, it is not plausible that P. aeruginosa is simultaneously co‐evolving in a gene‐for‐gene manner with all of its potential hosts, which include plants, nematodes, insects, and mammals. This prompts us to ask what is the driving force for co‐evolution of defense response in Arabidopsis and pathogenesis of P. aeruginosa, which might not have been subject to iterative cycles of evolutionary selections. Abstract : Pseudomonas aeruginosa type II‐secreted protease IV elicits an immune response in Arabidopsis through a novel signaling pathway that involves the heterotrimeric G protein complex and a scaffolding protein for mitogen‐activated protein kinase cascade. Intriguingly, the sensory complex and the mechanisms by which it mediates the protease IV response remain elusive.