The role of adiponectin in obesity-associated female-specific carcinogenesis. (October 2016)

• Record Type: Journal Article
• Authors: Nagaraju, Ganji Purnachandra; Rajitha, Balney; Aliya, Sheik; Kotipatruni, Rama P.; Madanraj, Appiya Santharam; Hammond, Anthea; Park, Dongkyoo; Chigurupati, Srinivasulu; Alam, Afroz; Pattnaik, Subasini
• Is Part Of: Cytokine & growth factor reviews. Volume 31(2016)
• Page Start: 37
• Page End: 48
• Publication Date: 2016-10
• Subjects: AdipoR1 adiponectin receptor 1 -- AdipoR2 adiponectin receptor 2 -- AMPK adenosine monophosphate-activated protein kinase -- ATF3 activating transcription factor 3 -- BiFC bimolecular fluorescence complementation -- BMI body mass index -- BRCA1 breast cancer type 1 -- BRCA2 breast cancer type 2 -- cAMP cyclic adenosine monophosphate -- CA 125 cancer antigen 125 -- COX-2 cyclooxygenase-2 -- DCIS ductal carcinoma in situ -- EGF epidermal growth factor -- eNOS endothelial nitric oxide synthase -- ERp44 ER protein of 44 kDa -- Ero1-Lα ER oxidoreductase 1-Lα -- FRET/BRET fluorescence and bioluminescence resonance energy transfer -- FTO fat mass and obesity -- GLUT4 glucose transporter 4 -- GPCRs G protein-coupled receptors -- GWAS genome-wide association studies -- HBOC hereditary breast and ovarian cancer -- HDL high-density lipoprotein -- HMW high-molecular weight -- HPV human papilloma virus -- IGF insulin-like growth factor -- IL-8 interleukin 8 -- IRS1 insulin receptor substrate 1 -- L/A leptin/adiponectin -- LMW low molecular weight -- LPA2 lipoprotein associated phospholipase A2 -- MMW medium molecular weight -- MS metabolic syndrome -- NAFLD non-alcoholic fatty liver disease -- NCHS National Center for Health Statistics -- NFATc4 nuclear factor of activated T cells 4 -- NF-κB nuclear factor-kappaB -- PAI-1 plasminogen activator inhibitor-1 -- PI3K phosphatidylinositol 3 kinase -- PKA protein kinase A -- PPARα peroxisome proliferator-activated receptor alpha -- PPAR-γ peroxisome proliferator-activated receptor gamma -- PTMs post-translational modifications -- PTEN phosphatase tensin homolog -- SIRT-1 sirtuin 1 -- SP surfactant proteins -- TNF-α tumor necrosis factor -- VEGF vascular endothelial growth factor -- WHO World Health Organization; Adiponectin -- Obesity -- Cervical cancer -- Ovarian cancer -- Endometrial cancer -- Breast cancer; Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2016.03.014
• Languages: English
• ISSNs: 1359-6101

Abstract

Graphical abstract: Highlights: We review the association between obesity, adiponectin levels and female-specific malignances. We consider the role of adiponectin in the context of female-specific malignances. We discuss the potential of applying adiponectin as a therapeutic molecule for female-specific malignances. Abstract: Adipose tissue is a highly vascularized endocrine organ, and its secretion profiles may vary with obesity. Adiponectin is secreted by adipocytes that make up adipose tissue. Worldwide, obesity has been designated a serious health problem among women and is associated with a variety of metabolic disorders and an increased risk of developing cancer of the cervix, ovaries, uterus (uterine/endometrial), and breast. In this review, the potential link between obesity and female-specific malignancies is comprehensively presented by discussing significant features of the intriguing and complex molecule, adiponectin, with a focus on recent findings highlighting its molecular mechanism of action in female-specific carcinogenesis.