New transgenic ALS/FTD models on the rat‐walk: An Editorial Highlight for 'Increased Ubqln2 expression causes neuron death in transgenic rats'. (10th October 2016)

• Record Type: Journal Article
• Authors: Stegmüller, Judith; Synofzik, Matthis
• Is Part Of: Journal of neurochemistry. Volume 139(2016)Supplement 2
• Page Start: 159
• Page End: 161
• Publication Date: 2016-10-10
• Subjects: Neurochemistry -- Periodicals; 616.8042
• DOI: 10.1111/jnc.13775
• Languages: English
• ISSNs: 0022-3042

Abstract

Abstract : This Editorial highlights a study by Huang and colleagues in the current issue of Journal of Neurochemistry. The authors introduce a novel ALS‐FTD (amyotrophic lateral sclerosis‐frontotemporal dementia) rat model to explore the role of the UBLQN2 gene that has previously been associated with familial ALS‐FTD. Over‐expression of ubiquilin 2 in the cortex (CTX) and hippocampus of the rat results in ubiquilin 2 aggregates and neurodegeneration together with cognitive deficits. The new rat model not only gives insight into potential molecular underpinnings of ALS‐FTD, but also represents an important new tool for future research and therapeutic approaches. Read the highlighted article 'Increased Ubqln2 expression causes neuron death in transgenic rats' on page285 . Abstract : This Editorial highlights a study by Huang and colleagues in the current issue of Journal of Neurochemistry. The authors introduce a novel ALS‐FTD (amyotrophic lateral sclerosis‐frontotemporal dementia) rat model to explore the role of the UBLQN2 gene that has previously been associated with familial ALS‐FTD. Over‐expression of ubiquilin 2 in the cortex (CTX) and hippocampus of the rat results in ubiquilin 2 aggregates and neurodegeneration together with cognitive deficits. The new rat model not only gives insight into potential molecular underpinnings of ALS‐FTD, but also represents an important new tool for future research and therapeutic approaches. Read the highlighted article 'Increased Ubqln2 expression causes neuron death in transgenic rats' on page285 .