Special considerations in pregnant systemic sclerosis patients. (1st November 2016)

• Record Type: Journal Article
• Authors: Sobanski, Vincent; Launay, David; Depret, Sandrine; Ducloy-Bouthors, Anne-Sophie; Hachulla, Eric
• Is Part Of: Expert review of clinical immunology. Volume 12:Number 11(2016)
• Page Start: 1161
• Page End: 1173
• Publication Date: 2016-11-01
• Subjects: Systemic sclerosis -- connective tissue disease -- pregnancy -- scleroderma -- hypertension -- renal crisis -- preeclampsia -- placenta -- prematurity -- miscarriage; Clinical immunology -- Periodicals; 616.079
• DOI: 10.1080/1744666X.2016.1194201
• Languages: English
• ISSNs: 1744-666X

Abstract

ABSTRACT: Introduction : Evaluating the fertility and pregnancy outcomes in systemic sclerosis (SSc) women is challenging. Studies are still limited or subject to potential methodological biases. Areas covered : This work is a comprehensive review of the literature. We discuss the potential impact of SSc on women's pregnancy outcomes and the effects of pregnancy on SSc. We summarize the physiological changes during pregnancy and describe our experience. Expert commentary : Although the miscarriage rate does not appear increased in SSc, women are exposed to a higher risk of premature birth and intrauterine growth restriction compared with the general population. Early diffuse cutaneous SSc and use of corticosteroids are risk factors, whereas folic acid use prevents against premature birth. All SSc women wishing to conceive should be counselled during a preconception visit. Physiological changes arising during pregnancy may be the source of clinical problems in SSc women with organs with limited capacities.