Disseminated extracranial metastatic meningioma. (November 2016)

• Record Type: Journal Article
• Authors: Chua, Felicia H.Z.; Low, Sharon Y.Y.; Tham, Chee K.; Ding, Cristine; Wong, Chin F.; Nolan, Colum P.
• Is Part Of: Journal of clinical neuroscience. Volume 33(2016:Nov.)
• Page Start: 214
• Page End: 216
• Publication Date: 2016-11
• Subjects: Bevacizumab -- Meningioma -- Metastasis; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2016.01.038
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Meningiomas are usually low-grade, solitary lesions that rarely metastasize. The higher grade subtypes are notorious for resistance to conventional chemo-radiation therapies. Bevacizumab has shown efficacy in patients with recurrent and, or progressive anaplastic meningioma. We report a patient with recurrent anaplastic meningioma who had disease progression, despite bevacizumab treatment. Higher grade meningiomas remain therapeutically challenging and require further study. Abstract: Meningiomas are usually low-grade, solitary lesions that rarely metastasize. In this group of central nervous system tumours, the higher grade subtypes are notorious for resistance to conventional chemo-radiation therapies. Recent studies have shown efficacy in the use of bevacizumab in patients with recurrent and, or progressive anaplastic meningioma. The authors report a case of a young patient with recurrent anaplastic meningioma who despite being treated with bevacizumab, progressed with disease dissemination to multiple extracranial sites. Although the majority of meningiomas are amendable to treatment, the higher grade subtypes remain therapeutically challenging. The unexpected resistance to anti-angiogenic therapy in this patient adds another layer of complexity to an elusive subset of a supposedly benign disease. This patient report reflects the need for in-depth studies, molecular characterization and overall, better disease understanding in order to improve prognosis for affected patients.