Evaluating the protective effects of radon inhalation or ascorbic acid treatment after transient global cerebral ischemic injury in gerbils. Issue 11 (1st November 2016)

• Record Type: Journal Article
• Authors: Kataoka, Takahiro; Etani, Reo; Kanzaki, Norie; Sasaoka, Kaori; Kobashi, Yusuke; Hanamoto, Katsumi; Taguchi, Takehito; Yamaoka, Kiyonori
• Is Part Of: Journal of nuclear science and technology. Volume 53:Issue 11(2016)
• Page Start: 1681
• Page End: 1685
• Publication Date: 2016-11-01
• Subjects: Radon inhalation -- transient global ischemia -- antioxidative function -- ascorbic acid -- oxidative damage -- neuron -- gerbil; Nuclear engineering -- Periodicals; Nuclear physics -- Periodicals; Nuclear energy -- Periodicals; 621.4805
• DOI: 10.1080/00223131.2016.1198731
• Languages: English
• ISSNs: 0022-3131

Abstract

ABSTRACT: In this study, we compared the protective effects of radon inhalation and ascorbic acid administration on transient global cerebral ischemic injury in gerbils. Gerbils were treated with radon inhalation (2000 Bq/m 3, 24 hours) or ascorbic acid (100, 300, or 500 mg/kg body weight). Then, transient global cerebral ischemia was induced by bilateral occlusion of the common carotid artery. Results showed that the number of damaged neurons was significantly increased in gerbils that underwent ischemia compared with that in control gerbils. However, the number of damaged neurons in gerbils treated with radon or 500 mg/kg of ascorbic acid before ischemia was significantly lower than gerbils who were subjected to ischemia without any pretreatment, and the protective effects of radon inhalation were similar to the effects of administering 500 mg/kg ascorbic acid. The levels of superoxide dismutase (SOD) and total glutathione (t-GSH) in brain tissue were increased to a similar extent by pretreatment with radon inhalation or 500 mg/kg of ascorbic acid. These findings suggested that radon inhalation has a protective antioxidative effect against transient global cerebral ischemic injury similar to 500 mg/kg ascorbic acid treatment.