Deceleration capacity: A novel predictor for total mortality in patients with non-ischemic dilated cardiomyopathy. (15th October 2016)

• Record Type: Journal Article
• Authors: Demming, Thomas; Sandrock, Sarah; Kuhn, Christian; Kotzott, Laura; Tahmaz, Nihat; Bonnemeier, Hendrik
• Is Part Of: International journal of cardiology. Volume 221(2016)
• Page Start: 289
• Page End: 293
• Publication Date: 2016-10-15
• Subjects: ICD Internal cardioverter defibrillator -- LVEF Left ventricular ejection fraction -- ECG Electrocardiogram -- HRV Heart rate variability -- DC Deceleration capacity -- NICM Non ischemic dilated cardiomyopathy -- PRSA Phase rectified signal averaging -- NYHA New York Heart Association classification of Heart failure -- AF Atrial fibrillation -- SDNN Standard deviation of normal to normal intervals -- SDANN Standard deviation of averaged normal to normal intervals -- rMSSD Square root of the mean of the sum of squared differences between adjacent normal- to-normal intervals -- HF High frequency domain in power spectral density analysis -- LF Low frequency domain in power spectral density analysis -- HFpEF Heart failure with preserved ejection fraction (≥ 35%); Deceleration capacity -- Heart rate variability -- Non ischemic dilated cardiomyopathy; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2016.06.205
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Objectives: We hypothesized that deceleration capacity (DC), a novel marker of cardiac autonomic modulation, is an independent predictor for mortality in patients with non-ischemic dilated cardiomyopathy (NICM). Background: NICM is associated with a high risk for sudden cardiac death (SCD). However there are no clinically established parameters available for risk stratification beyond LVEF. DC has been previously shown to be a strong independent predictor for total mortality in patients after myocardial infarction. Methods: Holter-ECG recordings of 201 patients NICM (83.1% male, mean age: 61.4 years, mean LVEF: 33.3%) were analyzed by the method of phase-rectified-signal-averaging (PRSA) to obtain DC. Results: During a minimum follow-up of 40 month 59 patients died. Kaplan Meyer Analysis showed a significantly higher mortality in patients with a DC below 4.5 ms (log rank p = 0.012) irrespective to the presence of atrial fibrillation. Conclusions: Impaired DC is a powerful independent predictor for mortality in patients with NICM.