Exendin-4 inhibits growth and augments apoptosis of ovarian cancer cells. (15th November 2016)

• Record Type: Journal Article
• Authors: He, Wenjing; Yu, Shuang; Wang, Liantang; He, Mian; Cao, Xiaopei; Li, Yanbing; Xiao, Haipeng
• Is Part Of: Molecular and cellular endocrinology. Volume 436(2016)
• Page Start: 240
• Page End: 249
• Publication Date: 2016-11-15
• Subjects: Exendin-4 -- Inhibit growth -- Augments apoptosis -- Ovarian cancer cells; T2DM type 2 diabetes mellitus -- GLP-1 glucagon-like peptide -1 -- GLP-1 R glucagon-like peptide -1 receptor -- IHC immunohistochemical -- BSA bovine serum albumin -- c-AMP cyclic adenosine monophosphate; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2016.07.032
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: Glucagon-like peptide (GLP)-1 promotes proliferation and survival in β-cell; however, whether GLP-1 receptor agonists promote growth of human ovarian cancer cells remain unknown. We aimed to explore the effects of GLP-1 agents on ovarian cancer cells. GLP-1 receptor expression in human ovarian cancer tissues was detected by immunohistochemical analysis. The effects of exendin-4, a GLP-1R agonist, were investigated on proliferation, migration and invasion, apoptosis in vitro and tumor formation in nude mice of ovarian cancer cells. Our study demonstrated that GLP-1R expressed in both human ovarian cancer tissues and cell lines. Exendin-4 inhibited growth, migration and invasion and enhanced apoptosis of ovarian cancer cells through inhibition of the PI3K/Akt pathway. And exendin-4 attenuated tumor formation by ovarian cancer cells in vivo. Our study suggests that GLP-1R agonists do not promote the growth of ovarian cancer and may even have anticancer effect on selected diabetic patients with ovarian cancer. Highlights: GLP-1R expresses in both human ovarian cancer tissues and cells. Exendin-4 inhibits growth and enhanced apoptosis of ovarian cancer cells. Exendin-4 plays an antitumor role via inhibition of Akt activation.