Effects of Interaction Between Ventricular Assist Device Assistance and Autoregulated Mock Circulation Including Frank–Starling Mechanism and Baroreflex. Issue 10 (19th November 2015)

• Record Type: Journal Article
• Authors: Jansen‐Park, So‐Hyun; Mahmood, Mohammad Nauzef; Müller, Indra; Turnhoff, Lisa Kathrin; Schmitz‐Rode, Thomas; Steinseifer, Ulrich; Sonntag, Simon Johannes
• Is Part Of: Artificial organs. Volume 40:Issue 10(2016:Oct.)
• Page Start: 981
• Page End: 991
• Publication Date: 2015-11-19
• Subjects: Mock heart circulation loop -- Frank–Starling mechanism -- Baroreflex -- Ventricular assist device -- Pressure–volume loop; Artificial organs -- Periodicals; 617.956
• DOI: 10.1111/aor.12635
• Languages: English
• ISSNs: 0160-564X

Abstract

Abstract: A mock heart circulation loop (MHCL) is a hydraulic model simulating the human circulatory system. It allows in vitro investigations of the interaction between cardiac assist devices and the human circulatory system. In this study, a preload sensitive MHCL, the MHCLAUTO, was developed to investigate the interaction between the left ventricle and left ventricular assist devices (LVADs). The Frank–Starling mechanism was modeled by regulating the stroke volume (SV) based on the measured mean diastolic left atrial pressure (MLAPdiast ). The baroreflex autoregulation mechanism was implemented to maintain a constant mean aortic pressure (MAP) by varying ventricular contractility (Emax ), heart rate (HR), afterload/systemic vascular resistance (SVR) and unstressed venous volume (UVV). The DP3 blood pump (Medos Medizintechnik GmbH) was used to simulate the LVAD. Characteristic parameters were measured in pathological conditions both with and without LVAD to assess the hemodynamic effect of LVAD on the MHCLAUTO . The results obtained from the MHCLAUTO show a high correlation to literature data. The study demonstrates the possibility of using the MHCLAUTO as a research tool to better understand the physiological interactions between cardiac implants and human circulation.