Gold Nanomaterials in Consumer Cosmetics Nanoproducts: Analyses, Characterization, and Dermal Safety Assessment. Issue 39 (26th August 2016)

• Record Type: Journal Article
• Authors: Cao, Mingjing; Li, Jiayang; Tang, Jinglong; Chen, Chunying; Zhao, Yuliang
• Is Part Of: Small. Volume 12:Issue 39(2016)
• Page Start: 5488
• Page End: 5496
• Publication Date: 2016-08-26
• Subjects: characterization -- cosmetic creams -- gold nanomaterials -- separation -- toxicity assessment; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201601574
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Establishment of analytical methods of engineered nanomaterials in consumer products for their human and environmental risk assessment becomes urgent for both academic and industrial needs. Owing to the difficulties and challenges around nanomaterials in complex media, proper chemical separation and biological assays of nanomaterials from nanoproducts needs to be firstly developed. Herein, a facile and rapid method to separate and analyze gold nanomaterials in cosmetics is reported. Gold nanomaterials are successfully separated from different facial or eye creams and their physiochemical properties are analyzed by quantitative and qualitative state‐of‐the art techniques with high sensitivity or high spatial resolution. In turn, a protocol including quantification of gold by inductively coupled plasma mass spectrometry and thorough characterization of morphology, size distribution, and surface property by electron microscopes, atomic force microscope, and X‐ray photoelectron spectroscope is developed. Subsequently, the preliminary toxicity assessment indicates that gold nanomaterials in cosmetic creams have no observable toxicity to human keratinocytes even after 24 h exposure up to a concentration of 200 μg mL −1 . The environmental scanning electron microscope reveals that gold nanomaterials are mostly attached on the cell membrane. Thus, the present study provides a full analysis protocol for toxicity assessment of gold nanomaterials in consumer products (cosmetic creams). Abstract : A practical protocol including separation, characterization, and toxicity assessment of gold nanomaterials in cosmetic creams is developed. Gold nanomaterials are successfully separated from facial or eye creams and their physiochemical properties are analyzed by several state‐of‐the art techniques. Subsequently, the preliminary toxicity assessments indicate that they have no observable toxicity to human keratinocytes.