The plasma 8-OHdG levels and oxidative stress following cholecystectomy: a randomised multicentre study of patients with minilaparotomy cholecystectomy versus laparoscopic cholecystectomy. (1st December 2016)

• Record Type: Journal Article
• Authors: Aspinen, Samuli; Harju, Jukka; Juvonen, Petri; Selander, Tuomas; Kokki, Hannu; Pulkki, Kari; Eskelinen, Matti Johannes
• Is Part Of: Scandinavian journal of gastroenterology. Volume 51:Number 12(2016)
• Page Start: 1507
• Page End: 1511
• Publication Date: 2016-12-01
• Subjects: Cholecystectomy -- minilaparotomy -- laparoscopy -- oxidative response; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.1080/00365521.2016.1208270
• Languages: English
• ISSNs: 0036-5521

Abstract

Abstract: Objective: The aim of the study was to evaluate the role of 8-OHdG (8-hydroxy-2′-deoxyguanosine) detecting oxidative stress response following cholecystectomy in a randomised multicentre study of patients with minilaparotomy cholecystectomy (MC) versus laparoscopic cholecystectomy (LC). Methods: Initially, 106 patients with non-complicated symptomatic gallstone disease were randomised into MC ( n = 56) or LC ( n = 50) groups. Plasma levels of the oxidative stress marker 8-OHdG measured at three time points; before (PRE), immediately after (POP1) and 6 h after operation (POP2). Results: The demographic variables and the surgical data were similar in the study groups. The plasma oxidative stress marker 8-OHdG concentrations following surgery in the MC versus LC patients were quite similar. There was no significant correlation between the individual values of the11-point numeric rating pain scale (NRS) versus the plasma 8-OHdG post-operatively in the MC and LC patients. However, there was a statistically significant correlation between the individual values of the plasma 8-OHdG (PRE) versus IL-10 (PRE) for the MC and LC patients ( r = 0.214, p = 0.037). There was also a statistically significant correlation between the individual values of the plasma 8-OHdG (POP2) versus IL-1β (POP2) for the MC and LC patients ( r = 0.25, p = 0.01). Conclusion: Our results suggest that the oxidative stress marker 8-OHdG concentrations following surgery in MC versus LC patients were quite similar. A new finding with possible clinical relevance is a correlation between the individual plasma values of the 8-OHdG versus anti-inflammatory interleukin IL-10 and 8-OHdG versus IL-1β (proinflammatory) in the MC and LC patients suggesting that inflammation and oxidative stress are related.