The role of titanium-prepared platelet-rich fibrin in palatal mucosal wound healing and histoconduction. (2nd October 2016)

• Record Type: Journal Article
• Authors: Ustaoğlu, Gülbahar; Ercan, Esra; Tunali, Mustafa
• Is Part Of: Acta odontologica Scandinavica. Volume 74:Number 7(2016)
• Page Start: 558
• Page End: 564
• Publication Date: 2016-10-02
• Subjects: Gingiva -- histoconduction -- platelet-rich fibrin -- tissue transplantation -- wound epithelization; Dentistry -- Periodicals; 617.6005
• DOI: 10.1080/00016357.2016.1219045
• Languages: English
• ISSNs: 0001-6357

Abstract

Abstract: Objective: We aimed to determine the clinical effects of titanium-prepared, platelet-rich fibrin (T-PRF) on human palatal mucosal wound healing (PMWH) and to identify its effect on time-dependent changes in palatal soft-tissue thickness (PSTT) in terms of histoconduction, which is a new concept. Materials and methods: Free gingival graft (FGG) donor sites were treated with T-PRF and compared with an untreated control group. The results of colour match and H2 O2 -bubbling tests for complete wound epithelization (CWE) were recorded on days 3, 7, 14 and 21. Pain level, number of analgesics used and bleeding status were recorded for the first 7 days. PSTT was measured at baseline and after 1 and 6 months. Results: Colour match scores of the test group were significantly higher than those of the control group at 7 and 14 days. CWE was observed at a higher frequency in the test group than in the control group on day 14. Post-operative bleeding prevalence was lower in the test group than in the control group for the first 2 days. A time-dependent decrease in PSTT was observed at 1 and 6 months in the control group compared with baseline (baseline, 4.23 ± 0.62 mm; 1 month, 4.01 ± 0.68 mm; and 6 months, 3.93 ± 0.69 mm). However, no significant difference was found in the test group (baseline, 4.29 ± 0.64 mm; 1 month, 4.61 ± 0.51 mm; and 6 months, 4.51 ± 0.58 mm). Conclusion: The T-PRF membrane exhibited positive effects on PMWH. T-PRF, which is a promising autogenous matrix for histoconduction, may also be preferred as an autogenous alternative to connective tissue grafts in the treatment of gingival recessions and peri-implant mucosal recessions.