Anxiety disorders are associated with early onset of heroin use and rapid transition to dependence in methadone maintained patients. (30th November 2016)

• Record Type: Journal Article
• Authors: Karsinti, Emily; Fortias, Maeva; Dupuy, Gaël; Ksouda, Kamilia; Laqueille, Xavier; Simonpoli, Anne-Marie; Touzeau, Didier; Avril, Elisabeth; Orizet, Cyrille; Belforte, Beatriz; Coeuru, Philippe; Polomeni, Pierre; Icick, Romain; Jarroir, Marine; Bloch, Vanessa; Scott, Jan; Lépine, Jean-Pierre; Bellivier, Frank; Vorspan, Florence
• Is Part Of: Psychiatry research. Volume 245(2016)
• Page Start: 423
• Page End: 426
• Publication Date: 2016-11-30
• Subjects: Heroin -- Cannabis -- Methadone -- Transition -- Risk factors -- Pathways; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2016.04.064
• Languages: English
• ISSNs: 0165-1781

Abstract

Abstract: Early onset of heroin use is a severity marker of heroin use disorder. We studied the interaction between early onset and rapid transition to heroin dependence recorded with retrospective interviews in 213 patients with severe heroin dependence and history of methadone maintenance treatment. General linear models were used to identify independent factors associated with early onset, factors associated with rapid transition to dependence, and a multivariate model was used to study the interaction of those two dimensions. Lifetime history of anxiety disorders and age at onset of cannabis use are shared common risk factors and are associated with the interaction. Highlights: Assessment was performed with validated questionnaires. Age of onset of heroin use was 20 years and duration from first to regular use was 1 year. Age at onset and duration was associated with lifetime anxiety disorders.