Signal‐domain optimization metrics for MPRAGE RF pulse design in parallel transmission at 7 tesla. Issue 5 (24th November 2015)

• Record Type: Journal Article
• Authors: Gras, V.; Vignaud, A.; Mauconduit, F.; Luong, M.; Amadon, A.; Le Bihan, D.; Boulant, N.
• Is Part Of: Magnetic resonance in medicine. Volume 76:Issue 5(2016)
• Page Start: 1431
• Page End: 1442
• Publication Date: 2015-11-24
• Subjects: ultra high field -- parallel transmission -- radiofrequency pulse design -- specific absorption rate -- MPRAGE -- kT‐points -- B1 inhomogeneity mitigation; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.26043
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract : Purpose: Standard radiofrequency pulse design strategies focus on minimizing the deviation of the flip angle from a target value, which is sufficient but not necessary for signal homogeneity. An alternative approach, based directly on the signal, here is proposed for the MPRAGE sequence, and is developed in the parallel transmission framework with the use of the k T ‐points parametrization. Methods: The flip angle‐homogenizing and the proposed methods were investigated numerically under explicit power and specific absorption rate constraints and tested experimentally in vivo on a 7 T parallel transmission system enabling real time local specific absorption rate monitoring. Radiofrequency pulse performance was assessed by a careful analysis of the signal and contrast between white and gray matter. Results: Despite a slight reduction of the flip angle uniformity, an improved signal and contrast homogeneity with a significant reduction of the specific absorption rate was achieved with the proposed metric in comparison with standard pulse designs. Conclusion: The proposed joint optimization of the inversion and excitation pulses enables significant reduction of the specific absorption rate in the MPRAGE sequence while preserving image quality. The work reported thus unveils a possible direction to increase the potential of ultra‐high field MRI and parallel transmission. Magn Reson Med 76:1431–1442, 2016. © 2015 International Society for Magnetic Resonance in Medicine