Osteogenesis: Bone Morphogenetic Protein‐2 Promotes Human Mesenchymal Stem Cell Survival and Resultant Bone Formation When Entrapped in Photocrosslinked Alginate Hydrogels (Adv. Healthcare Mater. 19/2016). Issue 19 (12th October 2016)

• Record Type: Journal Article
• Authors: Ho, Steve S.; Vollmer, Nina L.; Refaat, Motasem I.; Jeon, Oju; Alsberg, Eben; Lee, Mark A.; Leach, J. Kent
• Is Part Of: Advanced healthcare materials. Volume 5:Issue 19(2016)
• Page Start: 2500
• Page End: 2500
• Publication Date: 2016-10-12
• Subjects: bone morphogenetic protein‐2 -- mesenchymal stem cell -- osteogenesis -- photocrosslinking -- survival; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201670106
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : J. Kent Leach and co‐workers investigate the inhibition of apoptosis and promotion of survival and osteogenesis of human mesenchymal stem cells when entrapped in a photocrosslinkable alginate hydrogel on page 2501. The images show the gelation of BMP‐2 in alginate with mesenchymal stem cells to be implanted in a segmental defect. In vitro studies demonstrate improved survival of cells when stimulated with BMP‐2, translating to improved bone healing in vivo (as shown by microCT).