Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences. Issue 10 (31st August 2016)
- Record Type:
- Journal Article
- Title:
- Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences. Issue 10 (31st August 2016)
- Main Title:
- Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences
- Authors:
- Tietz, Silvia M.
Zwahlen, Marcel
Haghayegh Jahromi, Neda
Baden, Pascale
Lazarevic, Ivana
Enzmann, Gaby
Engelhardt, Britta - Abstract:
- Abstract : Considering the 3R rules of animal experimentation, we asked if refined scoring of experimental autoimmune encephalomyelitis (EAE) in mice improves documentation of clinical EAE allowing to perform a more powerful statistical analysis. Surprisingly, refined EAE scoring failed to improve statistical outcome comparing the overall disease courses between two groups of mice.
- Is Part Of:
- European journal of immunology. Volume 46:Issue 10(2016)
- Journal:
- European journal of immunology
- Issue:
- Volume 46:Issue 10(2016)
- Issue Display:
- Volume 46, Issue 10 (2016)
- Year:
- 2016
- Volume:
- 46
- Issue:
- 10
- Issue Sort Value:
- 2016-0046-0010-0000
- Page Start:
- 2481
- Page End:
- 2483
- Publication Date:
- 2016-08-31
- Subjects:
- Area under the curve -- Bland‐Altman plots -- Clinical scoring -- Experimental autoimmune encephalomyelitis -- Statistical analysis
Immunology -- Periodicals
616.079 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/eji.201546272 ↗
- Languages:
- English
- ISSNs:
- 0014-2980
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3829.730100
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 1272.xml