One-pot synthesis of oxoisoindoline-1, 2, 3-triazole hybrid by a Ugi–click reaction. Issue 20 (17th October 2016)

• Record Type: Journal Article
• Authors: Akrami, Sara; Firoozpour, Loghman; Goli-Garmroodi, Fereshteh; Moghimi, Setareh; Mahdavi, Mohammad; Zonouzi, Afsaneh; Foroumadi, Alireza
• Is Part Of: Synthetic communications. Volume 46:Issue 20(2016)
• Page Start: 1708
• Page End: 1712
• Publication Date: 2016-10-17
• Subjects: Click reaction -- multicomponent reaction -- one-pot synthesis -- 1, 2, 3-triazole -- Ugi reaction; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2016.1223313
• Languages: English
• ISSNs: 0039-7911

Abstract

ABSTRACT: 1, 2, 3-Triazole-3-oxoisoindoline-1-carboxamide system was successfully synthesized by using a combination of Ugi and click reactions. This two-step, one-pot synthesis was started by the reaction of 2-formyl benzoic acid, propargyl amine, and cyclohexyl isocyanide in ethanol. The resultant Ugi adduct underwent a copper-catalyzed click reaction, producing the desired products in good yields. GRAPHICAL ABSTRACT: