Chlamydia trachomatis infection and Vγ9Vδ2 Τ cells in women with recurrent spontaneous abortions. (26th August 2016)

• Record Type: Journal Article
• Authors: Voskakis, Ieronymos; Tsekoura, Christina; Keramitsoglou, Theodora; Tsantoulas, Evangelos; Deligeoroglou, Efthimios; Creatsas, George; Varla‐Leftherioti, Marighoula
• Is Part Of: American journal of reproductive immunology. Volume 76:Number 5(2016)
• Page Start: 358
• Page End: 363
• Publication Date: 2016-08-26
• Subjects: Chlamydia trachomatis infection -- recurrent spontaneous abortions -- γ9δ2 T cells; Human reproduction -- Immunological aspects -- Periodicals; 616.69206
• DOI: 10.1111/aji.12554
• Languages: English
• ISSNs: 1046-7408

Abstract

Abstract : Problem: Vγ9Vδ2 T cells (γ9δ2) are involved in antibacterial immune responses. The aim of this study was to look for associations between peripheral blood (PB) γ9δ2 T cells and cervix/vaginal Chlamydia trachomatis ( Ct ) infection in women with recurrent spontaneous abortions (RSA). Method of study: Peripheral blood samples were obtained from 201 RSA women within 10 days after they experienced a new miscarriage. γ9δ2 T cells and their percentage in total γδ T cells were compared between women who had been found and women who had not been found infected with Ct (last 6 months). Fertile women (82) served as control subjects. Results: The difference of mean percentages of γ9δ2 T cells between the abortion and control groups, and the Chlamydia (+) and Chlamydia (−) groups was highly statistically significant ( P <.00001). Significant difference was also found between the Chlamydia (+) and Chlamydia (−) group and the control group (ANOVA). Conclusion: The measurement of γ9δ2T cells may be useful to suspect possibly undiagnosed chlamydial infection in RSA women.