APSH YI-02 THE POLYMORPHISM IN ALDEHYDE DEHYDROGENASE-2 (ALDH2) GENE IS ASSOCIATED WITH MYOCARDIAL INFARCTION AND STROKE IN A CHINESE POPULATION. (September 2016)

• Record Type: Journal Article
• Authors: Liu, Xin; Chen, Weirong; Zhang, Hongye; Zhang, Wei; Liu, Lisheng; Wang, Xingyu
• Is Part Of: Journal of hypertension. Volume 34:(2016) Supplement 1
• Publication Date: 2016-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000500983.30024.a2
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Objective: Alcohol consumption has an important effect on coronary atherosclerotic heart disease (CAD). Acetaldehyde dehydrogenase 2 (ALDH2) is a key enzyme in alcohol metabolism. A G-to-A missense mutation of ALDH2 gene, rs671, which causes a Glu > Lys (504) substitution, was performed to detect the association with CAD and other relative diseases, but the results were not conclusive. The purpose of the present study was to determine whether this locus confers significant susceptibility to myocardial infarction and stroke in a Chinese population. Design and method: We conducted two case–control association studies (one cohort of 2325 myocardial infarction patients and 2620 unrelated controls, another cohort of 3960 stroke patients and 3654 controls)from the Chinese population. Genotyping of the rs671 SNP was performed by the TaqMan Real Time PCR method. Results: We found that rs671 (G allele) was significantly associated with myocardial infarction (odds ratio 1.21, 95% CI: 1.088–1.337, p = 0.00027, additive model), and logistic regression result indicated that the polymorphism was not associated with alcohol consumption and other risk factors. However, rs 671 (G allele) showed a protective effect on stroke patients without drinking (odds ratio 0.82, 95% CI: 0.741–0.908, p = 0.00033, additive model), and no relationship observed between SNP and stroke in patients with drinking. Conclusions: Our results indicate that, in the Chinese population, the ALDH2 variant rs671 is a risk factor of myocardial infarction but a protective factor of stroke without alcohol consumption. The role and pathway of ALDH2 involving in these diseases need more researches.