PS 02-44 URIC ACID CONCENTRATION, XANTHINE OXIDASE ACTIVITY AND SALT SENSITIVITY INDEX AS PREDICTORS FOR PRIMARY ARTERIAL HYPERTENSION – WHICH ONE IS THE BEST?. (September 2016)

• Record Type: Journal Article
• Authors: Radenkovic, Sonja; Stojanovic, Dijana; Kocic, Gordana
• Is Part Of: Journal of hypertension. Volume 34:(2016) Supplement 1
• Publication Date: 2016-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000500171.77327.80
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: The goal of the study was to measure plasma concentration of uric acid and xanthine oxidase (XO) activity and to determine index of sodium sensitivity in the group of patients with primary arterial hypertension, and to hypothesize among them, by multivariate modeling, parameters that represent best risk factors for development of primary arterial hypertension. Design and Method: We included 178 patients, mean age 59 ± 18.2 years. The patients had to have preserved kidney function, to be at least 5 years with diagnosed primary arterial hypertension, to be without a disorder manifested with uric arthropathy and without diuretic therapy for at last 6 months. Salt sensitivity index was calculated by dividing mean arterial pressure with natriuresis for 24 hours. XO activity was measured in plasma according to the liberation of uric acid by using xanthine as substrate in the absence of NADH. Uric acid serum concentration was measured spectrophotometrically. Results: Significant differences were found between groups in all evaluated parameters, acidum uricum (p = 0.002), XO activity (p = 0.002), and salt sensitivity index (p < 0.001). Non-adjusted OR showed that there was a significant risk for primary arterial hypertension with increased XO activity (OR = 1.015, p = 0.037), elevated uric acid concentration (OR = 1.058, p = 0.038), and high salt sensitivity index (OR = 1.821, p = 0.028). Comparing theses predictive values the highest significance for primary arterial hypertension was salt sensitivity index (OR = 1.821). Conclusions: Acidum uricum, XO activity, and salt sensitivity index were independent risk factors for primary arterial hypertension. Comparing OR of evaluated parameters the highest significance for hypertension had measuring salt sensitivity.