Ethanol impedes embryo transport and impairs oviduct epithelium. (16th May 2016)

• Record Type: Journal Article
• Authors: Xu, Tonghui; Yang, Qiuhong; Liu, Ruoxi; Wang, Wenfu; Wang, Shuanglian; Liu, Chuanyong; Li, Jingxin
• Is Part Of: Toxicology. Volume 357/358(2016)
• Page Start: 44
• Page End: 51
• Publication Date: 2016-05-16
• Subjects: TFI tubal factor infertility -- NO nitric oxide -- NOS nitric oxide synthase -- L-NAME L-NGnitroarginine methyl ester -- SEM scanning electron microscope -- AUC area under the curve; Alcohol -- Embryo transport -- Ectopic pregnancy -- Fertility -- Nitric oxide; Toxicology -- Periodicals; Chemicals -- Physiological effect -- Periodicals; 615.9005
• DOI: 10.1016/j.tox.2016.06.001
• Languages: English
• ISSNs: 0300-483X

Abstract

Abstract: Most studies have demonstrated that alcohol consumption is associated with decreased fertility. The aim of this study was to investigate the effects of alcohol on pre-implantation embryo transport and/or early embryo development in the oviduct. We reported here that ethanol concentration-dependently suppressed the spontaneous motility of isolated human oviduct strips (EC50 50 ± 6 mM), which was largely attenuated in the present of L-NAME, a classical nitric oxide synthase(NOS) competitive inhibitor. Notably, either acute or chronic alcohol intake delayed egg transport and retarded early development of the embryo in the mouse oviduct, which was largely rescued by co-administration of L-NAME in a acute alcohol intake group but not in chronic alcohol intake group. It is worth mentioning that the oviductal epithelium destruction was verified by scanning electron microscope (SEM) observations in chronic alcohol intake group. In conclusion, alcohol intake delayed egg transport and retarded early development of the embryo in the oviduct by suppressing the spontaneous motility of oviduct and/or impairing oviductal epithelium. These findings suggested that alcohol abuse increases the incident of ectopic pregnancy.