[PP.29.26] AMBULATORY ARTERIAL STIFFNESS INDEX IN PATIENTS WITH METABOLIC SYNDROME AND NEWLY DIAGNOSED HYPERTENSION BEFORE AND AFTER ONE YEAR OF TREATMENT WITH LOSARTANE AND TELMISARTANE. (September 2016)

• Record Type: Journal Article
• Authors: Rihacek, I.; Soucek, M.; Kianicka, B.; Frana, P.; Plachy, M.; Spac, J.
• Is Part Of: Journal of hypertension. Volume 34:(2016) Supplement 2
• Publication Date: 2016-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000492235.04624.48
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: To measure the ambulatory arterial stiffness index (AASI) and pulse pressure (PP) in patients with newly diagnosed hypertension and metabolic syndrome before and after 1 year of treatment with losartane or telmisartane once daily. Design and method: Blood pressure (BP) measurement using 24-hour ambulatory BP monitoring (ABPM, SpaceLabs 90207) according to the ESH criteria. Metabolic syndrome and hypertension defined by ATP III criteria. Fifty seven patients in two groups; 30 patients treated with telmisartane and 27 patients with losartane. PP pressure calculated as systolic minus diastolic BP, AASI defined as 1-regression slope of diastolic on systolic BP computed from 24-hour recording for each patient. Statistic evaluation before and after treatment using paired Students T-test. Results: Telmisartane (N = 30), before treatment: mean 24-hour ABPM 135/84 mmHg, PP 50, 8 ± 8, 7 mmHg, AASI 0, 37 ± 0, 01, after treatment: mean 24-hour ABPM 126/79 mmHg, difference −9/5 mmHg, P < 0, 01, PP 47, 4 ± 6, 0 mmHg, difference −3, 4 mmHg, P < 0, 01, AASI 0, 38 ± 0, 04, difference + 0, 01, P = 0, 642. Losartane (N = 27), before treatment: mean 24-hour ABPM 135/84 mmHg, PP 51, 2 ± 7 mmHg, AASI 0, 38 ± 0, 05, after treatment: mean 24-hour ABPM 124/77 mmHg, difference 11/7 mmHg, P < 0, 01, PP 46, 9 ± 5, 8 mmHg, difference −4, 3 mmHg, P < 0, 01, AASI 0, 38 ± 0, 04, difference 0, P = 0, 68. Conclusions: After treatment significantly decreased the value of 24-hour ABPM, and PP, AASI values were not significantly affected.