[PP.30.18] EFFECTS OF A COMBINED BLOOD PRESSURE AND LIPID-LOWERING NUTRACEUTICAL ON MILDLY HYPERTENSIVE HYPERCHOLESTEROLEMIC SUBJECTS: A PILOT, DOUBLE-BLIND, PLACEBO-CONTROLLED, RCT. (September 2016)

• Record Type: Journal Article
• Authors: Cicero, A.F.G.; Rosticci, M.; D'Addato, S.; Fogacci, F.; Urso, R.; Borghi, C.
• Is Part Of: Journal of hypertension. Volume 34:(2016) Supplement 2
• Publication Date: 2016-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000492253.96038.c3
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: A number of nutraceuticals have demonstrated to significantly lower blood pressure or lipid levels in humans. Our aim was to evaluate the effect of a combination of both blood pressure and lipid lowering nutraceuticals in mildly hypertensive hypercholesterolemic subjects. Figure. No caption available. Design and method: This is a pilot, double-blind, randomized, placebo-controlled, clinical trial carried out on 30 mildly hypertensive hypercholesterolemic subjects in primary prevention for cardiovascular disease, randomized to active treatment or placebo for 2 months. Active treatment contained red yeast rice extract (with 10 mg monacolin per dose), an NO-donor, magnesium, and vitamins. Results: The tested product was well-tolerated by all patients. Subjects in active treatment experienced a significant improvement in morning SBP, DBP, MAP, evening SBP, LDL-C and estimated CV risk vs. placebo (see table). Conclusions Conclusion: A combined blood pressure and lipid lowering nutraceutical improved morning SBP, DBP, MAP, evening SBP, LDL-C and estimated CV risk vs. placebo in mildly hypertensive hypercholesterolemic subjects.