[PP.08.03] COULD FLOW MEDIATED SLOWING CONSTITUTE A METHODOLOGICAL ALTERNATIVE TO THE CONVENTIONAL ECHO-TRACKING FLOW-MEDIATED DILATION TECHNIQUE FOR THE EVALUATION OF ENDOTHELIAL FUNCTION?. (September 2016)

• Record Type: Journal Article
• Authors: Pereira, T.; Almeida, A.; Maldonado, J.
• Is Part Of: Journal of hypertension. Volume 34:(2016) Supplement 2
• Publication Date: 2016-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000491775.36380.10
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: The Moens-Korteweg equation predicts changes in pulse wave velocity (PWV) following changes in arterial radius, therefore an increase in arterial radius, as seen in a reactive hyperaemia (RH) condition, should slow PWV over a given arterial segment. If this assumption is true, than the deceleration of PWV over the brachial artery (flow-mediated slowing – FMS) should be an equivalent signal of endothelial function during a conventional RH flow-mediated dilation (FMD) procedure. Our aim was to compare FMS with FMD after RH in healthy subjects, as part of a study that seeks to evaluate the clinical usefulness of FMS. Figure 1. Correlation of FMS and FMD. Figure. No caption available. Design and method: Cross-sectional study including 25 healthy participants (72% females), mean age 21.12 ± 0.73 years. FMD and FMS were simultaneously measured at baseline and 1 min after a ischemia period. Ischemia was induced by inflating a cuff for 5 min on the right forearm, 50mmHg above each participant's systolic blood pressure. FMS was measured as the absolute (δ) and percentual (%) change in carotid-radial PWV (PWV), measured with the Complior Analyse. Results: Mean baseline brachial diameter was 3.46 ± 0, 59 mm, and was smaller in females compared with males (3.12 ± 0, 22 mm versus 4.17 ± 0, 43 mm, respectively; p < 0.001). Mean FMD was 8.18 ± 3.65%, δPWV was −0.83 ± 0.70 m/s, and % PWV was 9.45 ± 8.31%, and were similar in males and females. A significant correlation was observed between both measures of FMS (δPWV and % PWV) and echo FMD: R = −0, 42 (p = 0, 04) and R = 0, 46 (p = 0, 02), respectively (cf. figure). FMS was shown to be dependent on the baseline brachial diameter, with smaller variations depicted for smaller baseline brachial diameters. Conclusions: FMS measured with the Complior Analyse device appears to be a promising and feasible method for measuring changes following RH, showing a significant correlation with FMD in young and healthy individuals, although further studies are needed to demonstrate the clinical usefulness of this method.