[PP.05.02] SERUM THROMBOSPONDIN-2 IS STRONGLY ASSOCIATED WITH INSULIN RESISTANCE IN A GENERAL POPULATION. (September 2016)

• Record Type: Journal Article
• Authors: Morikawa, N.; Adachi, H.; Enomoto, M.; Fukami, A.; Kumagai, E.; Nakamura, S.; Nohara, Y.; Nakao, E.; Tsuru, T.; Sakaue, A.; Kono, S.; Fukumoto, Y.
• Is Part Of: Journal of hypertension. Volume 34:(2016) Supplement 2
• Publication Date: 2016-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000491714.00941.51
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Serum thrombospondin (TSP)-2 is a glycoprotein expressed in extracellular matrix increasing during tissue remodeling. Recent studies have shown that TSP-2 is useful as a prognostic factor of patients with heart failure and associated with cardiovascular death. However, the clinical importance of serum TSP-2 in healthy subjects is still unknown. We examined the relations between TSP-2 and coronary risk factors. Design and method: A periodic epidemiological survey was performed in a community dwelling in Uku town, Nagasaki, Japan. A total of 445 residents received a health check-up examination including blood tests such as fasting serum levels of TSP-2. Insulin resistance was evaluated using HOMA-IR. All statistical analyses were performed using SAS system. Results: The mean age was 67 ± 9.4 years old. There are no significant differences between the ages and sexes and serum TSP-2 level (mean:20.9 ± 8.5ng/ml). We performed uni and multivariate analyses. Serum TSP-2 levels were significantly correlated to plasma glucose (p < 0.001), insulin (p < 0.001), HOMA-IR (p < 0.001), eGFR (p < 0.01; inversely), high sensitive CRP (p < 0.01) and NT-proBNP (p < 0.001). Moreover, in multiple stepwise linear regression analysis, TSP-2 levels were independently and significantly associated with HOMA-IR (p < 0.001), high sensitive CRP (p < 0.05), and NT-proBNP (p < 0.001). Conclusions: To the best of our knowledge, this is the first report to examine the significant relationship between TSP-2 and insulin resistance even in healthy subjects.