[OP.8E.06] A SUFFICIENT PROTEIN INTAKE SHOULD BE ENCOURAGED IN HYPERTENSIVE PATIENTS WITHOUT CHRONIC KIDNEY DISEASE: A LONG-TERM OUTCOMES STUDY. (September 2016)

• Record Type: Journal Article
• Authors: Lesiuk, C.; Courand, P.Y.; Milon, H.; Defforges-Ranc, A.; Fouque, D.; Harbaoui, B.; Lantelme, P.
• Is Part Of: Journal of hypertension. Volume 34:(2016) Supplement 2
• Publication Date: 2016-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000491620.83495.49
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Protein intake may have some benefits on reducing blood pressure and cardiovascular events, but their effects are still debated. The objective of this study was to test the prognostic value of protein intake assessed by 24-hour urinary urea in a cohort of hypertensive patients with preserved renal function. Design and method: A total of 1128 hypertensive patients were followed according to tertile of protein intake adjusted for ideal body weight (IBW): <0.70, 0.70–0.93 and >0.93 g/kg. Results: Baseline characteristics (mean±standard deviation) were age 45.1 ± 13.2 years, systolic/diastolic blood pressure 185 ± 32/107 ± 20 mmHg, and estimated glomerular filtration rate 82 ± 32 mL/min. After 10 years of follow-up, 289 deaths occurred, 202 of which were of cardiovascular cause. As shown in the Kaplan–Meier curves, the survival rates decreased for patients in the lowest tertile of protein intake IBW for all-cause mortality (P = 0.008), for cardiovascular mortality (P = 0.029) but not for stroke mortality (P = 0.29, Figure). Figure. No caption available. After adjustment for major cardiovascular risk factors, patients in the second and third tertiles of protein intake had a decreased risk of all-cause death (hazard ratio [95% confidence interval] 0.71[0.56–0.91]) and cardiovascular death (0.72[0.54–0.96]), but not of stroke death (0.72[0.41–1.28]) in comparison to patients in the low protein intake tertile. Normal–high protein intake had a more marked positive influence in a subset of the population: younger patients, low salt intake, without aortic atherosclerosis or previous cardiovascular events (Pinteraction<0.10 for all). Conclusions: This study demonstrates that a protein intake >0.7 g/kg IBW has a favorable effect, particularly in low-risk hypertensive patients. Physicians may encourage hypertensive patients to have normal or high protein diet in addition to low salt consumption, moderate alcohol consumption, and regular physical activity.