C-reactive protein levels and genetic variants of CRP as prognostic markers for combined cardiovascular endpoint (cardiovascular death, death from stroke, myocardial infarction, and stroke/TIA). (December 2016)

• Record Type: Journal Article
• Authors: Schulz, Susanne; Lüdike, Henriette; Lierath, Madlen; Schlitt, Axel; Werdan, Karl; Hofmann, Britt; Gläser, Christiane; Schaller, Hans-Günter; Reichert, Stefan
• Is Part Of: Cytokine. Volume 88(2016)
• Page Start: 71
• Page End: 76
• Publication Date: 2016-12
• Subjects: C-reactive protein -- Genetics -- Coronary vascular disease -- Prognostic factor; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2016.08.021
• Languages: English
• ISSNs: 1043-4666

Abstract

Highlights: Increased CRP level is a significant predictor for three-year CV outcome. In multivariate model increased CRP level was confirmed to be an independent risk factor. The GG genotype of rs1800947 was associated with the CV outcome in Kaplan-Meier- analysis. In cox regression the GG genotype showed a 1.99 higher risk for CV endpoint. All other SNPs were proven to be no predictor for three-year CV outcome. Abstract: Background: The aim of this analysis was to evaluate the importance of C-reactive protein levels and genetic variants of CRP as prognostic markers for further cardiovascular (CV) events (3-year follow-up) in a cohort of in-patients with cardiovascular disease (CVD) patients. Methods and results: Patients with angiographic proven CVD (n = 939) were prospectively included. The three-year CV outcome of the patients was evaluated considering the predefined, combined endpoint (CV death, death from stroke, myocardial infarction, and stroke/TIA). Polymorphisms rs1800947, rs1417938, rs1130864, rs3093077 were analysed. In Kaplan-Meier survival curve and Cox regression increased CRP levels of ⩾5 mg/l (log-rank test: p = 0.001, Cox regression: hazard ratio = 1.77, 95% CI: 1.2–2.7) and the GG genotype of rs1800947 (log-rank test: p = 0.01, Cox regression: hazard ratio = 1.99, 95% CI: 1.1–3.6) were associated with the incidence of the combined endpoint. Conclusions: Both a CRP level ⩾5 mg/l and SNP rs1800947 of the CRP gene were independent risk factors for further adverse CV events among patients with CVD within three years follow-up.